281306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4674891..4675594 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag QLG18_RS23070 Protein ID WP_282676469.1
Coordinates 4674891..4675232 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag QLG18_RS23075 Protein ID WP_282676470.1
Coordinates 4675253..4675594 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS23055 (4670385) 4670385..4671872 + 1488 WP_095885150.1 HEPN domain-containing protein -
QLG18_RS23065 (4673634) 4673634..4674641 - 1008 WP_282676468.1 restriction endonuclease -
QLG18_RS23070 (4674891) 4674891..4675232 - 342 WP_282676469.1 TA system toxin CbtA family protein Toxin
QLG18_RS23075 (4675253) 4675253..4675594 - 342 WP_282676470.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QLG18_RS23080 (4675605) 4675605..4676147 - 543 WP_282676471.1 DNA repair protein RadC -
QLG18_RS23085 (4676160) 4676160..4676600 - 441 WP_282676472.1 antirestriction protein -
QLG18_RS23090 (4676605) 4676605..4677453 - 849 WP_282676473.1 DUF932 domain-containing protein -
QLG18_RS23095 (4677573) 4677573..4678046 - 474 WP_282676474.1 hypothetical protein -
QLG18_RS23100 (4678118) 4678118..4678570 - 453 WP_000734321.1 hypothetical protein -
QLG18_RS23105 (4678606) 4678606..4679322 - 717 WP_282676475.1 WYL domain-containing protein -
QLG18_RS23110 (4679566) 4679566..4680441 - 876 WP_282676476.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4663278..4700398 37120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12704.66 Da        Isoelectric Point: 7.1648

>T281306 WP_282676469.1 NZ_CP124824:c4675232-4674891 [Klebsiella pneumoniae]
MKTLPATSPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGIILADAVNFLVEKYELVRIDRRGF
NWQEQSPYLGAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12788.33 Da        Isoelectric Point: 5.0491

>AT281306 WP_282676470.1 NZ_CP124824:c4675594-4675253 [Klebsiella pneumoniae]
MKSTSSENDSFLQWGLNRNVTPCFGARLVQEGNQLHYLADRVSITGEFSNAESLKLDEVFPRFISQMESMLTTSEMNPRY
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References