Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4634255..4635065 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QLG18_RS22860 Protein ID WP_004178461.1
Coordinates 4634255..4634788 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QLG18_RS22865 Protein ID WP_002887278.1
Coordinates 4634799..4635065 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS22855 (4633086) 4633086..4634207 + 1122 WP_016946712.1 cupin domain-containing protein -
QLG18_RS22860 (4634255) 4634255..4634788 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QLG18_RS22865 (4634799) 4634799..4635065 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QLG18_RS22870 (4635168) 4635168..4636601 - 1434 WP_048255468.1 Cu(+)/Ag(+) sensor histidine kinase -
QLG18_RS22875 (4636591) 4636591..4637274 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
QLG18_RS22880 (4637446) 4637446..4638831 + 1386 WP_264865422.1 efflux transporter outer membrane subunit -
QLG18_RS22885 (4638849) 4638849..4639181 + 333 WP_264865424.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T281305 WP_004178461.1 NZ_CP124824:c4634788-4634255 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT281305 WP_002887278.1 NZ_CP124824:c4635065-4634799 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References