Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2588364..2589952 | Replicon | chromosome |
Accession | NZ_CP124824 | ||
Organism | Klebsiella pneumoniae strain H53 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | QLG18_RS12820 | Protein ID | WP_251893309.1 |
Coordinates | 2588364..2589686 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
Locus tag | QLG18_RS12825 | Protein ID | WP_002904790.1 |
Coordinates | 2589686..2589952 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QLG18_RS12805 (2583420) | 2583420..2585921 | + | 2502 | WP_115668000.1 | fimbria/pilus outer membrane usher protein | - |
QLG18_RS12810 (2585909) | 2585909..2586913 | + | 1005 | WP_048337093.1 | fimbrial protein | - |
QLG18_RS12815 (2587055) | 2587055..2588347 | + | 1293 | WP_040089018.1 | glycoside hydrolase family 10 protein | - |
QLG18_RS12820 (2588364) | 2588364..2589686 | - | 1323 | WP_251893309.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
QLG18_RS12825 (2589686) | 2589686..2589952 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
QLG18_RS12830 (2590218) | 2590218..2590544 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
QLG18_RS12835 (2590541) | 2590541..2591041 | - | 501 | WP_015958401.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
QLG18_RS12840 (2591019) | 2591019..2592398 | - | 1380 | WP_004176204.1 | nucleobase:cation symporter-2 family protein | - |
QLG18_RS12845 (2592744) | 2592744..2593898 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
QLG18_RS12850 (2593879) | 2593879..2594802 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49077.39 Da Isoelectric Point: 7.2850
>T281301 WP_251893309.1 NZ_CP124824:c2589686-2588364 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYHLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWLAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYHLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWLAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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