Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2588364..2589952 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QLG18_RS12820 Protein ID WP_251893309.1
Coordinates 2588364..2589686 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QLG18_RS12825 Protein ID WP_002904790.1
Coordinates 2589686..2589952 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS12805 (2583420) 2583420..2585921 + 2502 WP_115668000.1 fimbria/pilus outer membrane usher protein -
QLG18_RS12810 (2585909) 2585909..2586913 + 1005 WP_048337093.1 fimbrial protein -
QLG18_RS12815 (2587055) 2587055..2588347 + 1293 WP_040089018.1 glycoside hydrolase family 10 protein -
QLG18_RS12820 (2588364) 2588364..2589686 - 1323 WP_251893309.1 type II toxin-antitoxin system HipA family toxin Toxin
QLG18_RS12825 (2589686) 2589686..2589952 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QLG18_RS12830 (2590218) 2590218..2590544 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QLG18_RS12835 (2590541) 2590541..2591041 - 501 WP_015958401.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QLG18_RS12840 (2591019) 2591019..2592398 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
QLG18_RS12845 (2592744) 2592744..2593898 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QLG18_RS12850 (2593879) 2593879..2594802 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49077.39 Da        Isoelectric Point: 7.2850

>T281301 WP_251893309.1 NZ_CP124824:c2589686-2588364 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYHLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWLAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT281301 WP_002904790.1 NZ_CP124824:c2589952-2589686 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References