Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814917..815574 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QLG18_RS04025 Protein ID WP_002916310.1
Coordinates 815164..815574 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QLG18_RS04020 Protein ID WP_002916312.1
Coordinates 814917..815183 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS03995 (810125) 810125..811558 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QLG18_RS04000 (811677) 811677..812405 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
QLG18_RS04005 (812455) 812455..812766 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QLG18_RS04010 (812930) 812930..813589 + 660 WP_002916317.1 hemolysin III family protein -
QLG18_RS04015 (813688) 813688..814671 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
QLG18_RS04020 (814917) 814917..815183 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QLG18_RS04025 (815164) 815164..815574 + 411 WP_002916310.1 protein YgfX Toxin
QLG18_RS04030 (815581) 815581..816102 - 522 WP_178963023.1 flavodoxin FldB -
QLG18_RS04035 (816203) 816203..817099 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QLG18_RS04040 (817122) 817122..817835 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QLG18_RS04045 (817841) 817841..819574 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281296 WP_002916310.1 NZ_CP124824:815164-815574 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281296 WP_002916312.1 NZ_CP124824:814917-815183 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References