Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1985..2544 Replicon plasmid unnamed2
Accession NZ_CP124821
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QLG17_RS26900 Protein ID WP_000421259.1
Coordinates 2269..2544 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag QLG17_RS26895 Protein ID WP_001178087.1
Coordinates 1985..2269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS26890 (QLG17_26890) 46..1077 + 1032 WP_000907881.1 plasmid replication initiator RepA -
QLG17_RS26895 (QLG17_26895) 1985..2269 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
QLG17_RS26900 (QLG17_26900) 2269..2544 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG17_RS26905 (QLG17_26905) 2650..2847 + 198 Protein_3 hypothetical protein -
QLG17_RS26910 (QLG17_26910) 3116..3382 - 267 WP_000627832.1 hypothetical protein -
QLG17_RS26915 (QLG17_26915) 3382..3600 - 219 Protein_5 hypothetical protein -
QLG17_RS26920 (QLG17_26920) 3628..4230 - 603 WP_000521606.1 ProQ/FINO family protein -
QLG17_RS26925 (QLG17_26925) 4406..5458 - 1053 WP_000655519.1 hypothetical protein -
QLG17_RS26930 (QLG17_26930) 5671..6261 - 591 WP_001401589.1 hypothetical protein -
QLG17_RS26935 (QLG17_26935) 6261..6515 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..86154 86154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T281292 WP_000421259.1 NZ_CP124821:2269-2544 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT281292 WP_001178087.1 NZ_CP124821:1985-2269 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References