Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4421337..4421991 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QLG17_RS22075 Protein ID WP_000244777.1
Coordinates 4421584..4421991 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QLG17_RS22070 Protein ID WP_000354046.1
Coordinates 4421337..4421603 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS22050 (4417425) 4417425..4418858 - 1434 WP_024221758.1 6-phospho-beta-glucosidase BglA -
QLG17_RS22055 (4418903) 4418903..4419214 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QLG17_RS22060 (4419378) 4419378..4420037 + 660 WP_000250294.1 hemolysin III family protein -
QLG17_RS22065 (4420114) 4420114..4421094 - 981 WP_000886093.1 tRNA-modifying protein YgfZ -
QLG17_RS22070 (4421337) 4421337..4421603 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QLG17_RS22075 (4421584) 4421584..4421991 + 408 WP_000244777.1 protein YgfX Toxin
QLG17_RS22080 (4422031) 4422031..4422552 - 522 WP_001055874.1 flavodoxin FldB -
QLG17_RS22085 (4422664) 4422664..4423560 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QLG17_RS22090 (4423585) 4423585..4424295 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QLG17_RS22095 (4424301) 4424301..4426034 + 1734 WP_000813202.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T281286 WP_000244777.1 NZ_CP124819:4421584-4421991 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT281286 WP_000354046.1 NZ_CP124819:4421337-4421603 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References