Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3911032..3911786 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name ataT Uniprot ID A0A7U9LH62
Locus tag QLG17_RS19445 Protein ID WP_001400419.1
Coordinates 3911032..3911517 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag QLG17_RS19450 Protein ID WP_000801912.1
Coordinates 3911508..3911786 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS19425 (3906197) 3906197..3906955 + 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
QLG17_RS19430 (3906937) 3906937..3908535 - 1599 WP_001232936.1 DNA-binding transcriptional regulator RtcR -
QLG17_RS19435 (3908724) 3908724..3909950 + 1227 WP_001105483.1 RNA-splicing ligase RtcB -
QLG17_RS19440 (3909954) 3909954..3910982 + 1029 WP_024221621.1 RNA 3'-terminal phosphate cyclase -
QLG17_RS19445 (3911032) 3911032..3911517 - 486 WP_001400419.1 GNAT family N-acetyltransferase Toxin
QLG17_RS19450 (3911508) 3911508..3911786 - 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
QLG17_RS19455 (3911853) 3911853..3914558 - 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17692.65 Da        Isoelectric Point: 9.4066

>T281283 WP_001400419.1 NZ_CP124819:c3911517-3911032 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSTGLSRVYVICIVNTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT281283 WP_000801912.1 NZ_CP124819:c3911786-3911508 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LH62

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References