Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3864264..3865064 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name ataT Uniprot ID U9Y257
Locus tag QLG17_RS19225 Protein ID WP_000342447.1
Coordinates 3864537..3865064 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID U9Y285
Locus tag QLG17_RS19220 Protein ID WP_001277109.1
Coordinates 3864264..3864530 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS19200 (3859922) 3859922..3860590 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QLG17_RS19205 (3860583) 3860583..3861641 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QLG17_RS19210 (3861886) 3861886..3862740 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QLG17_RS19215 (3863011) 3863011..3864114 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QLG17_RS19220 (3864264) 3864264..3864530 + 267 WP_001277109.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QLG17_RS19225 (3864537) 3864537..3865064 + 528 WP_000342447.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QLG17_RS19230 (3865061) 3865061..3865444 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
QLG17_RS19235 (3865868) 3865868..3866977 + 1110 WP_052915153.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QLG17_RS19240 (3867025) 3867025..3867951 + 927 WP_000003013.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QLG17_RS19245 (3867948) 3867948..3869225 + 1278 WP_000803782.1 branched chain amino acid ABC transporter permease LivM -
QLG17_RS19250 (3869222) 3869222..3869989 + 768 WP_000082096.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.63 Da        Isoelectric Point: 7.0284

>T281282 WP_000342447.1 NZ_CP124819:3864537-3865064 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDHSIQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.37 Da        Isoelectric Point: 10.0863

>AT281282 WP_001277109.1 NZ_CP124819:3864264-3864530 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AVKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LUM2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LUN0

References