Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3821450..3822081 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LJQ2
Locus tag QLG17_RS18970 Protein ID WP_001259387.1
Coordinates 3821450..3821725 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QLG17_RS18975 Protein ID WP_000593555.1
Coordinates 3821722..3822081 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS18955 (3816454) 3816454..3817521 + 1068 WP_000361517.1 HlyD family efflux transporter periplasmic adaptor subunit -
QLG17_RS18960 (3817518) 3817518..3820253 + 2736 WP_052915154.1 ribosome-associated ATPase/putative transporter RbbA -
QLG17_RS18965 (3820253) 3820253..3821377 + 1125 WP_001314210.1 ABC transporter permease -
QLG17_RS18970 (3821450) 3821450..3821725 + 276 WP_001259387.1 type II toxin-antitoxin system HicA family toxin Toxin
QLG17_RS18975 (3821722) 3821722..3822081 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QLG17_RS18980 (3822131) 3822131..3822991 - 861 WP_001131788.1 class II aldolase -
QLG17_RS18985 (3823023) 3823023..3823292 - 270 WP_000933061.1 HPr family phosphocarrier protein -
QLG17_RS18990 (3823282) 3823282..3824790 - 1509 WP_001400448.1 FGGY-family carbohydrate kinase -
QLG17_RS18995 (3824783) 3824783..3826141 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
QLG17_RS19000 (3826218) 3826218..3826499 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
QLG17_RS19005 (3826496) 3826496..3826969 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10214.91 Da        Isoelectric Point: 10.7076

>T281281 WP_001259387.1 NZ_CP124819:3821450-3821725 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESQVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT281281 WP_000593555.1 NZ_CP124819:3821722-3822081 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LJQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References