Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3568906..3569707 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag QLG17_RS17815 Protein ID WP_001094437.1
Coordinates 3568906..3569283 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag QLG17_RS17820 Protein ID WP_001390338.1
Coordinates 3569330..3569707 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS17775 (3564483) 3564483..3564890 + 408 WP_000228583.1 LcrR family type III secretion system chaperone CesD2 -
QLG17_RS17780 (3564926) 3564926..3565147 + 222 WP_001053840.1 type III secretion system LEE needle filament protein EscF -
QLG17_RS17785 (3565153) 3565153..3565431 + 279 WP_000245816.1 type III secretion system LEE needle protein cochaperone EscG -
QLG17_RS17790 (3565516) 3565516..3566262 + 747 WP_000931693.1 type III secretion system LEE effector EspF -
QLG17_RS17795 (3566502) 3566502..3566809 - 308 Protein_3470 IS3 family transposase -
QLG17_RS17800 (3567274) 3567274..3568119 - 846 WP_001274561.1 DUF4942 domain-containing protein -
QLG17_RS17805 (3568204) 3568204..3568401 - 198 WP_000772032.1 DUF957 domain-containing protein -
QLG17_RS17810 (3568421) 3568421..3568909 - 489 WP_000761716.1 DUF5983 family protein -
QLG17_RS17815 (3568906) 3568906..3569283 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
QLG17_RS17820 (3569330) 3569330..3569707 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QLG17_RS17825 (3569870) 3569870..3570091 - 222 WP_000692345.1 DUF987 domain-containing protein -
QLG17_RS17830 (3570154) 3570154..3570630 - 477 WP_001535682.1 RadC family protein -
QLG17_RS17835 (3570646) 3570646..3571119 - 474 WP_000855064.1 antirestriction protein -
QLG17_RS17840 (3571461) 3571461..3572279 - 819 WP_001535681.1 DUF932 domain-containing protein -
QLG17_RS17845 (3572397) 3572397..3572592 - 196 Protein_3480 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island mph(B) / sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B espG / escE / cesAB / escK / escL / escR / escS / escT / escU / etgA / cesD / escC / sepD / escJ / escI / sepZ/espZ / cesL / escV / escN / escO / sepQ/escQ / espH / cesF / map / tir / cesT / eae / escD / sepL / espA / espD / espB / cesD2 / escF / escG / espF 3531953..3609931 77978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T281280 WP_001094437.1 NZ_CP124819:c3569283-3568906 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T281280 NZ_CP124819:c3569283-3568906 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT281280 WP_001390338.1 NZ_CP124819:c3569707-3569330 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT281280 NZ_CP124819:c3569707-3569330 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References