Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3005052..3005549 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QLG17_RS15115 Protein ID WP_001173343.1
Coordinates 3005052..3005225 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QLG17_RS15120 Protein ID WP_000398619.1
Coordinates 3005253..3005549 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS15105 (3001722) 3001722..3003179 + 1458 WP_000856822.1 dipeptide/tripeptide permease DtpC -
QLG17_RS15110 (3003416) 3003416..3004933 + 1518 WP_001295074.1 lysine--tRNA ligase -
QLG17_RS15115 (3005052) 3005052..3005225 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QLG17_RS15120 (3005253) 3005253..3005549 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QLG17_RS15125 (3005776) 3005776..3006048 - 273 WP_000405653.1 GNAT family N-acetyltransferase -
QLG17_RS15130 (3006060) 3006060..3006290 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QLG17_RS15135 (3006471) 3006471..3008102 + 1632 WP_022581427.1 sensor histidine kinase -
QLG17_RS15140 (3008099) 3008099..3008818 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T281279 WP_001173343.1 NZ_CP124819:c3005225-3005052 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT281279 WP_000398619.1 NZ_CP124819:c3005549-3005253 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References