Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2127897..2128515 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QLG17_RS10985 Protein ID WP_001291435.1
Coordinates 2128297..2128515 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QLG17_RS10980 Protein ID WP_000344800.1
Coordinates 2127897..2128271 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS10970 (2122986) 2122986..2124179 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QLG17_RS10975 (2124202) 2124202..2127351 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QLG17_RS10980 (2127897) 2127897..2128271 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QLG17_RS10985 (2128297) 2128297..2128515 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QLG17_RS10990 (2128687) 2128687..2129238 + 552 WP_000102564.1 maltose O-acetyltransferase -
QLG17_RS10995 (2129354) 2129354..2129824 + 471 WP_000136192.1 YlaC family protein -
QLG17_RS11000 (2129988) 2129988..2131538 + 1551 WP_024221674.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QLG17_RS11005 (2131580) 2131580..2131933 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QLG17_RS11015 (2132312) 2132312..2132623 + 312 WP_000409911.1 MGMT family protein -
QLG17_RS11020 (2132654) 2132654..2133226 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281275 WP_001291435.1 NZ_CP124819:2128297-2128515 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT281275 WP_000344800.1 NZ_CP124819:2127897-2128271 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References