Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4841700..4842316 | Replicon | chromosome |
Accession | NZ_CP124813 | ||
Organism | Citrobacter freundii strain CF12 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0J1MQ96 |
Locus tag | QLG15_RS23510 | Protein ID | WP_003028682.1 |
Coordinates | 4841700..4842074 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A6B5NTK4 |
Locus tag | QLG15_RS23515 | Protein ID | WP_043018956.1 |
Coordinates | 4842074..4842316 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QLG15_RS23495 (4839203) | 4839203..4840105 | + | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
QLG15_RS23500 (4840102) | 4840102..4840737 | + | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
QLG15_RS23505 (4840734) | 4840734..4841663 | + | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
QLG15_RS23510 (4841700) | 4841700..4842074 | - | 375 | WP_003028682.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
QLG15_RS23515 (4842074) | 4842074..4842316 | - | 243 | WP_043018956.1 | CopG family transcriptional regulator | Antitoxin |
QLG15_RS23520 (4842522) | 4842522..4843430 | + | 909 | WP_044701816.1 | alpha/beta hydrolase | - |
QLG15_RS23525 (4843581) | 4843581..4844522 | - | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
QLG15_RS23530 (4844567) | 4844567..4845004 | - | 438 | WP_003028671.1 | D-aminoacyl-tRNA deacylase | - |
QLG15_RS23535 (4845001) | 4845001..4845873 | - | 873 | WP_003028669.1 | virulence factor BrkB family protein | - |
QLG15_RS23540 (4845867) | 4845867..4846466 | - | 600 | WP_016151258.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13674.89 Da Isoelectric Point: 9.5622
>T281266 WP_003028682.1 NZ_CP124813:c4842074-4841700 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
Download Length: 375 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1MQ96 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B5NTK4 |