Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4841700..4842316 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag QLG15_RS23510 Protein ID WP_003028682.1
Coordinates 4841700..4842074 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag QLG15_RS23515 Protein ID WP_043018956.1
Coordinates 4842074..4842316 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS23495 (4839203) 4839203..4840105 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
QLG15_RS23500 (4840102) 4840102..4840737 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
QLG15_RS23505 (4840734) 4840734..4841663 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
QLG15_RS23510 (4841700) 4841700..4842074 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
QLG15_RS23515 (4842074) 4842074..4842316 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
QLG15_RS23520 (4842522) 4842522..4843430 + 909 WP_044701816.1 alpha/beta hydrolase -
QLG15_RS23525 (4843581) 4843581..4844522 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
QLG15_RS23530 (4844567) 4844567..4845004 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
QLG15_RS23535 (4845001) 4845001..4845873 - 873 WP_003028669.1 virulence factor BrkB family protein -
QLG15_RS23540 (4845867) 4845867..4846466 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T281266 WP_003028682.1 NZ_CP124813:c4842074-4841700 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT281266 WP_043018956.1 NZ_CP124813:c4842316-4842074 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References