281265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4658033..4658699 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag QLG15_RS22625 Protein ID WP_044702260.1
Coordinates 4658340..4658699 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag QLG15_RS22620 Protein ID WP_003844682.1
Coordinates 4658033..4658350 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS22590 (4653700) 4653700..4654524 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
QLG15_RS22595 (4654593) 4654593..4655816 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
QLG15_RS22600 (4655818) 4655818..4656630 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
QLG15_RS22605 (4656682) 4656682..4657038 - 357 WP_032948294.1 hypothetical protein -
QLG15_RS22610 (4657180) 4657180..4657341 + 162 WP_003841416.1 phage protein -
QLG15_RS22615 (4657745) 4657745..4658023 + 279 WP_044702262.1 putative addiction module antidote protein -
QLG15_RS22620 (4658033) 4658033..4658350 - 318 WP_003844682.1 helix-turn-helix transcriptional regulator Antitoxin
QLG15_RS22625 (4658340) 4658340..4658699 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG15_RS22630 (4658913) 4658913..4659602 + 690 WP_003841421.1 dipeptidase PepE -
QLG15_RS22635 (4659668) 4659668..4661299 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T281265 WP_044702260.1 NZ_CP124813:c4658699-4658340 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT281265 WP_003844682.1 NZ_CP124813:c4658350-4658033 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References