Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4098521..4099175 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag QLG15_RS19920 Protein ID WP_003026936.1
Coordinates 4098521..4098928 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag QLG15_RS19925 Protein ID WP_003026938.1
Coordinates 4098909..4099175 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS19900 (4094469) 4094469..4096202 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
QLG15_RS19905 (4096208) 4096208..4096921 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QLG15_RS19910 (4096945) 4096945..4097841 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
QLG15_RS19915 (4097955) 4097955..4098476 + 522 WP_003026933.1 flavodoxin FldB -
QLG15_RS19920 (4098521) 4098521..4098928 - 408 WP_003026936.1 protein YgfX Toxin
QLG15_RS19925 (4098909) 4098909..4099175 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
QLG15_RS19930 (4099432) 4099432..4100412 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
QLG15_RS19935 (4100506) 4100506..4101165 - 660 WP_003838267.1 hemolysin III family protein -
QLG15_RS19940 (4101328) 4101328..4101639 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
QLG15_RS19945 (4101692) 4101692..4102420 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
QLG15_RS19950 (4102541) 4102541..4103974 + 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T281264 WP_003026936.1 NZ_CP124813:c4098928-4098521 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT281264 WP_003026938.1 NZ_CP124813:c4099175-4098909 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References