281263

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4049687..4050348 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag QLG15_RS19620 Protein ID WP_000698542.1
Coordinates 4049687..4050010 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag QLG15_RS19625 Protein ID WP_167736232.1
Coordinates 4050031..4050348 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS19595 (4045029) 4045029..4045607 + 579 WP_044700788.1 tyrosine-type recombinase/integrase -
QLG15_RS19600 (4045701) 4045701..4045898 + 198 WP_044700790.1 hypothetical protein -
QLG15_RS19605 (4045880) 4045880..4046188 + 309 WP_170864030.1 hypothetical protein -
QLG15_RS19610 (4046596) 4046596..4047093 - 498 WP_044700793.1 hypothetical protein -
QLG15_RS19615 (4047417) 4047417..4048585 + 1169 WP_100216202.1 IS3 family transposase -
QLG15_RS19620 (4049687) 4049687..4050010 - 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
QLG15_RS19625 (4050031) 4050031..4050348 - 318 WP_167736232.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QLG15_RS19630 (4050367) 4050367..4050588 - 222 WP_000691995.1 DUF987 domain-containing protein -
QLG15_RS19635 (4050597) 4050597..4051073 - 477 WP_000811694.1 RadC family protein -
QLG15_RS19640 (4051089) 4051089..4051547 - 459 WP_016538084.1 antirestriction protein -
QLG15_RS19645 (4051633) 4051633..4051869 - 237 WP_000004273.1 DUF905 domain-containing protein -
QLG15_RS19650 (4051947) 4051947..4052357 - 411 WP_000912997.1 hypothetical protein -
QLG15_RS19655 (4052424) 4052424..4052861 - 438 WP_024198335.1 hypothetical protein -
QLG15_RS19660 (4052903) 4052903..4053439 - 537 WP_000219797.1 DUF4339 domain-containing protein -
QLG15_RS19665 (4053465) 4053465..4054175 - 711 WP_024198336.1 hypothetical protein -
QLG15_RS19670 (4054384) 4054384..4055208 - 825 WP_000197385.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4041065..4089877 48812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T281263 WP_000698542.1 NZ_CP124813:c4050010-4049687 [Citrobacter freundii]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11816.47 Da        Isoelectric Point: 6.9367

>AT281263 WP_167736232.1 NZ_CP124813:c4050348-4050031 [Citrobacter freundii]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSSQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure

References