Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1220760..1221380 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QLG15_RS05830 Protein ID WP_002892050.1
Coordinates 1220760..1220978 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag QLG15_RS05835 Protein ID WP_003021733.1
Coordinates 1221006..1221380 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS05795 (1215993) 1215993..1216622 + 630 WP_003835929.1 membrane protein -
QLG15_RS05800 (1216687) 1216687..1217040 + 354 WP_003831033.1 DUF1428 family protein -
QLG15_RS05805 (1217092) 1217092..1218645 - 1554 WP_044699371.1 EAL domain-containing protein -
QLG15_RS05810 (1218834) 1218834..1219094 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
QLG15_RS05815 (1219096) 1219096..1219236 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
QLG15_RS05820 (1219315) 1219315..1219785 - 471 WP_003021724.1 YlaC family protein -
QLG15_RS05825 (1219902) 1219902..1220453 - 552 WP_044699372.1 maltose O-acetyltransferase -
QLG15_RS05830 (1220760) 1220760..1220978 - 219 WP_002892050.1 HHA domain-containing protein Toxin
QLG15_RS05835 (1221006) 1221006..1221380 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
QLG15_RS05840 (1221868) 1221868..1225017 - 3150 WP_003021736.1 efflux RND transporter permease AcrB -
QLG15_RS05845 (1225040) 1225040..1226233 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281258 WP_002892050.1 NZ_CP124813:c1220978-1220760 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT281258 WP_003021733.1 NZ_CP124813:c1221380-1221006 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References