Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 239985..240616 Replicon chromosome
Accession NZ_CP124813
Organism Citrobacter freundii strain CF12

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag QLG15_RS01130 Protein ID WP_003837806.1
Coordinates 239985..240260 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag QLG15_RS01135 Protein ID WP_003837808.1
Coordinates 240257..240616 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG15_RS01120 (236036) 236036..238783 + 2748 WP_282625876.1 ribosome-associated ATPase/putative transporter RbbA -
QLG15_RS01125 (238783) 238783..239907 + 1125 WP_003837801.1 ABC transporter permease -
QLG15_RS01130 (239985) 239985..240260 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
QLG15_RS01135 (240257) 240257..240616 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QLG15_RS01140 (240729) 240729..241130 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
QLG15_RS01145 (241180) 241180..241758 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
QLG15_RS01150 (241821) 241821..242870 - 1050 WP_003023393.1 AI-2E family transporter -
QLG15_RS01155 (243004) 243004..244221 + 1218 WP_032950436.1 MFS transporter -
QLG15_RS01160 (244225) 244225..244782 - 558 WP_003837816.1 DcrB family lipoprotein -
QLG15_RS01165 (244855) 244855..245520 - 666 WP_088169168.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T281255 WP_003837806.1 NZ_CP124813:239985-240260 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT281255 WP_003837808.1 NZ_CP124813:240257-240616 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References