281251

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4692372..4693038 Replicon chromosome
Accession NZ_CP124809
Organism Citrobacter freundii strain CF13

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag QLG16_RS22740 Protein ID WP_044702260.1
Coordinates 4692679..4693038 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag QLG16_RS22735 Protein ID WP_003844682.1
Coordinates 4692372..4692689 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG16_RS22705 (4688039) 4688039..4688863 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
QLG16_RS22710 (4688932) 4688932..4690155 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
QLG16_RS22715 (4690157) 4690157..4690969 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
QLG16_RS22720 (4691021) 4691021..4691377 - 357 WP_032948294.1 hypothetical protein -
QLG16_RS22725 (4691519) 4691519..4691680 + 162 WP_003841416.1 phage protein -
QLG16_RS22730 (4692084) 4692084..4692362 + 279 WP_044702262.1 putative addiction module antidote protein -
QLG16_RS22735 (4692372) 4692372..4692689 - 318 WP_003844682.1 helix-turn-helix transcriptional regulator Antitoxin
QLG16_RS22740 (4692679) 4692679..4693038 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG16_RS22745 (4693252) 4693252..4693941 + 690 WP_003841421.1 dipeptidase PepE -
QLG16_RS22750 (4694007) 4694007..4695638 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T281251 WP_044702260.1 NZ_CP124809:c4693038-4692679 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT281251 WP_003844682.1 NZ_CP124809:c4692689-4692372 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References