Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1221536..1222156 Replicon chromosome
Accession NZ_CP124809
Organism Citrobacter freundii strain CF13

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QLG16_RS05845 Protein ID WP_002892050.1
Coordinates 1221536..1221754 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag QLG16_RS05850 Protein ID WP_003021733.1
Coordinates 1221782..1222156 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG16_RS05810 (1216769) 1216769..1217398 + 630 WP_003835929.1 membrane protein -
QLG16_RS05815 (1217463) 1217463..1217816 + 354 WP_003831033.1 DUF1428 family protein -
QLG16_RS05820 (1217868) 1217868..1219421 - 1554 WP_044699371.1 EAL domain-containing protein -
QLG16_RS05825 (1219610) 1219610..1219870 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
QLG16_RS05830 (1219872) 1219872..1220012 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
QLG16_RS05835 (1220091) 1220091..1220561 - 471 WP_003021724.1 YlaC family protein -
QLG16_RS05840 (1220678) 1220678..1221229 - 552 WP_044699372.1 maltose O-acetyltransferase -
QLG16_RS05845 (1221536) 1221536..1221754 - 219 WP_002892050.1 HHA domain-containing protein Toxin
QLG16_RS05850 (1221782) 1221782..1222156 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
QLG16_RS05855 (1222644) 1222644..1225793 - 3150 WP_003021736.1 efflux RND transporter permease AcrB -
QLG16_RS05860 (1225816) 1225816..1227009 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281244 WP_002892050.1 NZ_CP124809:c1221754-1221536 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT281244 WP_003021733.1 NZ_CP124809:c1222156-1221782 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References