Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 89714..90450 Replicon plasmid unnamed1
Accession NZ_CP124805
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag QLG20_RS27615 Protein ID WP_003026803.1
Coordinates 89968..90450 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QLG20_RS27610 Protein ID WP_003026799.1
Coordinates 89714..89980 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS27575 (QLG20_27565) 85558..85920 - 363 WP_004206665.1 arsenite efflux transporter metallochaperone ArsD -
QLG20_RS27580 (QLG20_27570) 85972..86322 - 351 WP_004206664.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
QLG20_RS27585 (QLG20_27575) 86680..86928 + 249 WP_004193994.1 hypothetical protein -
QLG20_RS27590 (QLG20_27580) 86925..88136 + 1212 WP_032415728.1 hypothetical protein -
QLG20_RS27595 (QLG20_27585) 88270..88761 + 492 WP_004206662.1 hypothetical protein -
QLG20_RS27600 (QLG20_27590) 88822..89025 + 204 WP_004206661.1 HHA domain-containing protein -
QLG20_RS27605 (QLG20_27595) 89039..89269 + 231 WP_004206660.1 hypothetical protein -
QLG20_RS27610 (QLG20_27600) 89714..89980 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QLG20_RS27615 (QLG20_27605) 89968..90450 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
QLG20_RS27620 (QLG20_27610) 90651..92054 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
QLG20_RS27625 (QLG20_27615) 92083..92715 - 633 WP_001567369.1 hypothetical protein -
QLG20_RS27630 (QLG20_27620) 92941..94287 + 1347 WP_077253535.1 ISNCY family transposase -
QLG20_RS27635 (QLG20_27625) 94336..94731 + 396 WP_004143398.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..174299 174299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T281238 WP_003026803.1 NZ_CP124805:89968-90450 [Klebsiella variicola]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT281238 WP_003026799.1 NZ_CP124805:89714-89980 [Klebsiella variicola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References