Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5501175..5501800 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name vapC Uniprot ID A0A1F2M041
Locus tag QLG20_RS26745 Protein ID WP_008807903.1
Coordinates 5501175..5501558 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QLG20_RS26750 Protein ID WP_004150355.1
Coordinates 5501558..5501800 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS26730 (QLG20_26720) 5498541..5499443 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QLG20_RS26735 (QLG20_26725) 5499440..5500075 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
QLG20_RS26740 (QLG20_26730) 5500072..5501001 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QLG20_RS26745 (QLG20_26735) 5501175..5501558 - 384 WP_008807903.1 type II toxin-antitoxin system VapC family toxin Toxin
QLG20_RS26750 (QLG20_26740) 5501558..5501800 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QLG20_RS26755 (QLG20_26745) 5502005..5502922 + 918 WP_064180736.1 alpha/beta hydrolase -
QLG20_RS26760 (QLG20_26750) 5502937..5503878 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
QLG20_RS26765 (QLG20_26755) 5503923..5504360 - 438 WP_008807906.1 D-aminoacyl-tRNA deacylase -
QLG20_RS26770 (QLG20_26760) 5504357..5505217 - 861 WP_008807907.1 virulence factor BrkB family protein -
QLG20_RS26775 (QLG20_26765) 5505211..5505810 - 600 WP_008807908.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281236 WP_008807903.1 NZ_CP124804:c5501558-5501175 [Klebsiella variicola]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYELHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281236 WP_004150355.1 NZ_CP124804:c5501800-5501558 [Klebsiella variicola]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M041

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References