Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4845234..4845810 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag QLG20_RS23620 Protein ID WP_012542979.1
Coordinates 4845523..4845810 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag QLG20_RS23615 Protein ID WP_022065028.1
Coordinates 4845234..4845536 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS23590 (QLG20_23580) 4840643..4841707 - 1065 WP_008807596.1 DUF2955 domain-containing protein -
QLG20_RS23595 (QLG20_23585) 4841697..4842764 - 1068 WP_039102796.1 HlyD family secretion protein -
QLG20_RS23600 (QLG20_23590) 4842771..4843235 - 465 WP_008807598.1 MarR family transcriptional regulator -
QLG20_RS23605 (QLG20_23595) 4843401..4843565 - 165 WP_008807599.1 DUF1127 domain-containing protein -
QLG20_RS23610 (QLG20_23600) 4843743..4845155 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
QLG20_RS23615 (QLG20_23605) 4845234..4845536 - 303 WP_022065028.1 BrnA antitoxin family protein Antitoxin
QLG20_RS23620 (QLG20_23610) 4845523..4845810 - 288 WP_012542979.1 BrnT family toxin Toxin
QLG20_RS23625 (QLG20_23615) 4845978..4846397 - 420 WP_008807601.1 FosA5 family fosfomycin resistance glutathione transferase -
QLG20_RS23630 (QLG20_23620) 4846391..4847299 - 909 WP_012542980.1 LysR family transcriptional regulator -
QLG20_RS23635 (QLG20_23625) 4847386..4848168 + 783 WP_012542981.1 NAD(P)H-dependent oxidoreductase -
QLG20_RS23640 (QLG20_23630) 4848310..4848894 + 585 WP_004182816.1 TetR/AcrR family transcriptional regulator -
QLG20_RS23645 (QLG20_23635) 4848916..4849719 + 804 WP_012542983.1 winged helix-turn-helix domain-containing protein -
QLG20_RS23650 (QLG20_23640) 4849716..4850234 + 519 WP_023297001.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T281234 WP_012542979.1 NZ_CP124804:c4845810-4845523 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11320.98 Da        Isoelectric Point: 10.3129

>AT281234 WP_022065028.1 NZ_CP124804:c4845536-4845234 [Klebsiella variicola]
MSMVKHKRGNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References