Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1813996..1814586 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QLG20_RS08780 Protein ID WP_023322934.1
Coordinates 1814254..1814586 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1F2LZQ3
Locus tag QLG20_RS08775 Protein ID WP_012541132.1
Coordinates 1813996..1814253 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS08755 (QLG20_08750) 1809606..1810181 + 576 WP_023322936.1 hypothetical protein -
QLG20_RS08760 (QLG20_08755) 1810358..1811194 + 837 WP_124037817.1 alpha/beta hydrolase -
QLG20_RS08765 (QLG20_08760) 1811401..1812372 + 972 WP_016161433.1 sensor domain-containing diguanylate cyclase -
QLG20_RS08770 (QLG20_08765) 1812369..1813469 - 1101 WP_124037818.1 phosphotransferase -
QLG20_RS08775 (QLG20_08770) 1813996..1814253 + 258 WP_012541132.1 antitoxin Antitoxin
QLG20_RS08780 (QLG20_08775) 1814254..1814586 + 333 WP_023322934.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLG20_RS08790 (QLG20_08785) 1814909..1816345 + 1437 WP_042948427.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
QLG20_RS08800 (QLG20_08795) 1816718..1818172 - 1455 WP_124037819.1 AMP nucleosidase -
QLG20_RS08805 (QLG20_08800) 1818303..1818548 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11768.58 Da        Isoelectric Point: 9.2926

>T281226 WP_023322934.1 NZ_CP124804:1814254-1814586 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPGTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9420.91 Da        Isoelectric Point: 4.4915

>AT281226 WP_012541132.1 NZ_CP124804:1813996-1814253 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZQ3

References