Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799302..799959 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QLG20_RS03955 Protein ID WP_002916310.1
Coordinates 799549..799959 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QLG20_RS03950 Protein ID WP_002916312.1
Coordinates 799302..799568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS03920 (QLG20_03920) 794523..795254 - 732 WP_282676406.1 MurR/RpiR family transcriptional regulator -
QLG20_RS03925 (QLG20_03925) 795305..795433 + 129 Protein_770 ASCH domain-containing protein -
QLG20_RS03930 (QLG20_03930) 795445..796521 - 1077 WP_000227969.1 IS110 family transposase -
QLG20_RS03935 (QLG20_03935) 796805..796990 + 186 Protein_772 ASCH domain-containing protein -
QLG20_RS03940 (QLG20_03940) 797154..797813 + 660 WP_008806429.1 hemolysin III family protein -
QLG20_RS03945 (QLG20_03945) 798073..799056 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
QLG20_RS03950 (QLG20_03950) 799302..799568 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QLG20_RS03955 (QLG20_03955) 799549..799959 + 411 WP_002916310.1 protein YgfX Toxin
QLG20_RS03960 (QLG20_03960) 799966..800487 - 522 WP_008806427.1 flavodoxin FldB -
QLG20_RS03965 (QLG20_03965) 800588..801484 + 897 WP_124037651.1 site-specific tyrosine recombinase XerD -
QLG20_RS03970 (QLG20_03970) 801507..802220 + 714 WP_282676292.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QLG20_RS03975 (QLG20_03975) 802226..803959 + 1734 WP_124037652.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 795445..796521 1076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281224 WP_002916310.1 NZ_CP124804:799549-799959 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281224 WP_002916312.1 NZ_CP124804:799302-799568 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References