Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 734161..734936 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QLG20_RS03620 Protein ID WP_064170005.1
Coordinates 734451..734936 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag QLG20_RS03615 Protein ID WP_046881921.1
Coordinates 734161..734454 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS03595 (QLG20_03595) 729417..730019 - 603 WP_012540553.1 short chain dehydrogenase -
QLG20_RS03600 (QLG20_03600) 730117..731028 + 912 WP_124037642.1 LysR family transcriptional regulator -
QLG20_RS03605 (QLG20_03605) 731029..732177 - 1149 WP_101139729.1 PLP-dependent aspartate aminotransferase family protein -
QLG20_RS03610 (QLG20_03610) 732189..733565 - 1377 WP_016161835.1 cystathionine beta-synthase -
QLG20_RS03615 (QLG20_03615) 734161..734454 + 294 WP_046881921.1 DUF1778 domain-containing protein Antitoxin
QLG20_RS03620 (QLG20_03620) 734451..734936 + 486 WP_064170005.1 GNAT family N-acetyltransferase Toxin
QLG20_RS03625 (QLG20_03625) 735640..736232 + 593 Protein_712 hypothetical protein -
QLG20_RS03630 (QLG20_03630) 736329..736545 + 217 Protein_713 transposase -
QLG20_RS03640 (QLG20_03640) 737061..737774 - 714 WP_008806478.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 736329..736481 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17618.64 Da        Isoelectric Point: 8.5178

>T281223 WP_064170005.1 NZ_CP124804:734451-734936 [Klebsiella variicola]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDGKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLRDLVH
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10868.52 Da        Isoelectric Point: 10.2633

>AT281223 WP_046881921.1 NZ_CP124804:734161-734454 [Klebsiella variicola]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEPQK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References