Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 196868..197628 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag QLG20_RS00960 Protein ID WP_124037534.1
Coordinates 197143..197628 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag QLG20_RS00955 Protein ID WP_124037532.1
Coordinates 196868..197155 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS00930 (QLG20_00930) 191902..193074 + 1173 WP_124037526.1 MFS transporter -
QLG20_RS00935 (QLG20_00935) 193205..194191 + 987 WP_178075512.1 LacI family DNA-binding transcriptional regulator -
QLG20_RS00940 (QLG20_00940) 194252..195382 - 1131 WP_095033069.1 YvcK family protein -
QLG20_RS00945 (QLG20_00945) 195617..196204 + 588 WP_167382661.1 sugar O-acetyltransferase -
QLG20_RS00950 (QLG20_00950) 196220..196744 + 525 WP_124037530.1 phosphoribosyltransferase family protein -
QLG20_RS00955 (QLG20_00955) 196868..197155 + 288 WP_124037532.1 DUF1778 domain-containing protein Antitoxin
QLG20_RS00960 (QLG20_00960) 197143..197628 + 486 WP_124037534.1 GNAT family N-acetyltransferase Toxin
QLG20_RS00965 (QLG20_00965) 197969..198121 + 153 WP_012967075.1 type I toxin-antitoxin system toxin HokA -
QLG20_RS00970 (QLG20_00970) 198423..200042 + 1620 WP_072125586.1 ATP-binding cassette domain-containing protein -
QLG20_RS00975 (QLG20_00975) 200141..200353 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QLG20_RS00980 (QLG20_00980) 200606..200896 - 291 WP_002921931.1 HTH-type transcriptional regulator -
QLG20_RS00985 (QLG20_00985) 201142..202497 - 1356 WP_008806885.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17697.41 Da        Isoelectric Point: 9.1865

>T281221 WP_124037534.1 NZ_CP124804:197143-197628 [Klebsiella variicola]
VGSLTAPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEANNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10941.63 Da        Isoelectric Point: 4.5256

>AT281221 WP_124037532.1 NZ_CP124804:196868-197155 [Klebsiella variicola]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADD
PVIEKLLARKPQWEV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References