281220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1800322..1800953 Replicon chromosome
Accession NZ_CP124777
Organism Lachnoanaerobaculum gingivalis strain SHL-20230108WGSARO1-L360107582

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QJR73_RS08465 Protein ID WP_282668493.1
Coordinates 1800322..1800729 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K0XI72
Locus tag QJR73_RS08470 Protein ID WP_007593116.1
Coordinates 1800726..1800953 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR73_RS08445 (QJR73_08445) 1797979..1798284 - 306 WP_128673028.1 ribosomal L7Ae/L30e/S12e/Gadd45 family protein -
QJR73_RS08450 (QJR73_08450) 1798271..1798555 - 285 WP_128673029.1 YlxR family protein -
QJR73_RS08455 (QJR73_08455) 1798533..1799720 - 1188 WP_128673030.1 transcription termination factor NusA -
QJR73_RS08460 (QJR73_08460) 1799739..1800245 - 507 WP_282668492.1 ribosome maturation factor RimP -
QJR73_RS08465 (QJR73_08465) 1800322..1800729 - 408 WP_282668493.1 type II toxin-antitoxin system VapC family toxin Toxin
QJR73_RS08470 (QJR73_08470) 1800726..1800953 - 228 WP_007593116.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJR73_RS08475 (QJR73_08475) 1801061..1801747 - 687 WP_282668494.1 SH3 domain-containing protein -
QJR73_RS08480 (QJR73_08480) 1801758..1802786 - 1029 WP_282668495.1 N-acetylmuramoyl-L-alanine amidase -
QJR73_RS08485 (QJR73_08485) 1803052..1804896 + 1845 WP_282668496.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15313.85 Da        Isoelectric Point: 6.2236

>T281220 WP_282668493.1 NZ_CP124777:c1800729-1800322 [Lachnoanaerobaculum gingivalis]
MRYMLDTNICIYIIKNKPESVVKELKRHDPTEICISAITYAELIHGVEKSMAVDKNRLALTLLLSNIEVLDFDINAANNY
GKIRTYLEKQGTPIGPLDMMIAAHAQSLGYSIVTNNIKEFMRVPNLEVCNWVEQA

Download         Length: 408 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8728.15 Da        Isoelectric Point: 4.7570

>AT281220 WP_007593116.1 NZ_CP124777:c1800953-1800726 [Lachnoanaerobaculum gingivalis]
MLSAKIFENGRSQAVRLPKEYRFCCDEVMVNKIGDVLILLPKNSKWDSFITAIDMFSDDFMVDRGEIPVQKREEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K0XI72

References