Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4188793..4189462 Replicon chromosome
Accession NZ_CP124754
Organism Serratia sp. K-E0102

Toxin (Protein)


Gene name cptA Uniprot ID A0A2V4FX75
Locus tag SSARUM2_RS19915 Protein ID WP_033649453.1
Coordinates 4188793..4189215 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag SSARUM2_RS19920 Protein ID WP_004931679.1
Coordinates 4189196..4189462 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM2_RS19895 (SSARUM2_003979) 4184682..4185200 + 519 WP_033635825.1 flavodoxin FldB -
SSARUM2_RS19900 (SSARUM2_003980) 4185238..4186602 - 1365 WP_041036554.1 cell envelope integrity protein CreD -
SSARUM2_RS19905 (SSARUM2_003981) 4186683..4188101 - 1419 WP_033654070.1 two-component system sensor histidine kinase CreC -
SSARUM2_RS19910 (SSARUM2_003982) 4188098..4188793 - 696 WP_049232287.1 two-component system response regulator CreB -
SSARUM2_RS19915 (SSARUM2_003983) 4188793..4189215 - 423 WP_033649453.1 protein YgfX Toxin
SSARUM2_RS19920 (SSARUM2_003984) 4189196..4189462 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
SSARUM2_RS19925 (SSARUM2_003985) 4189783..4190775 + 993 WP_049194803.1 tRNA-modifying protein YgfZ -
SSARUM2_RS19930 (SSARUM2_003986) 4190814..4191311 - 498 WP_033649451.1 DUF2165 domain-containing protein -
SSARUM2_RS19935 (SSARUM2_003987) 4191462..4192136 - 675 WP_038871224.1 hemolysin III family protein -
SSARUM2_RS19940 (SSARUM2_003988) 4192320..4192928 + 609 WP_025304127.1 HD domain-containing protein -
SSARUM2_RS19945 (SSARUM2_003989) 4192961..4193887 - 927 WP_033635835.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16471.59 Da        Isoelectric Point: 10.8114

>T281216 WP_033649453.1 NZ_CP124754:c4189215-4188793 [Serratia sp. K-E0102]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT281216 WP_004931679.1 NZ_CP124754:c4189462-4189196 [Serratia sp. K-E0102]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FX75

Antitoxin

Source ID Structure

References