Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3104821..3105452 Replicon chromosome
Accession NZ_CP124754
Organism Serratia sp. K-E0102

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag SSARUM2_RS14905 Protein ID WP_033640020.1
Coordinates 3104821..3105219 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag SSARUM2_RS14910 Protein ID WP_041035628.1
Coordinates 3105219..3105452 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM2_RS14885 (SSARUM2_002977) 3099921..3100736 - 816 WP_047571544.1 5'-nucleotidase, lipoprotein e(P4) family -
SSARUM2_RS14890 (SSARUM2_002978) 3101065..3101469 - 405 WP_041035624.1 flagellar protein FlhE -
SSARUM2_RS14895 (SSARUM2_002979) 3101469..3103547 - 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
SSARUM2_RS14900 (SSARUM2_002980) 3103540..3104691 - 1152 WP_015378261.1 flagellar biosynthesis protein FlhB -
SSARUM2_RS14905 (SSARUM2_002981) 3104821..3105219 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
SSARUM2_RS14910 (SSARUM2_002982) 3105219..3105452 - 234 WP_041035628.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SSARUM2_RS14915 (SSARUM2_002983) 3105578..3106222 - 645 WP_004934858.1 protein phosphatase CheZ -
SSARUM2_RS14920 (SSARUM2_002984) 3106233..3106622 - 390 WP_004934862.1 chemotaxis response regulator CheY -
SSARUM2_RS14925 (SSARUM2_002985) 3106725..3107774 - 1050 WP_060438544.1 chemotaxis response regulator protein-glutamate methylesterase -
SSARUM2_RS14930 (SSARUM2_002986) 3107774..3108646 - 873 WP_060438543.1 protein-glutamate O-methyltransferase CheR -
SSARUM2_RS14935 (SSARUM2_002987) 3108684..3110300 - 1617 WP_033653630.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T281212 WP_033640020.1 NZ_CP124754:c3105219-3104821 [Serratia sp. K-E0102]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT281212 WP_041035628.1 NZ_CP124754:c3105452-3105219 [Serratia sp. K-E0102]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References