Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14716..15317 Replicon chromosome
Accession NZ_CP124754
Organism Serratia sp. K-E0102

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag SSARUM2_RS00070 Protein ID WP_033649548.1
Coordinates 14716..15096 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag SSARUM2_RS00075 Protein ID WP_004933932.1
Coordinates 15096..15317 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM2_RS00045 (SSARUM2_000009) 9969..11249 + 1281 WP_047569945.1 DUF3748 domain-containing protein -
SSARUM2_RS00050 (SSARUM2_000010) 11280..11627 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
SSARUM2_RS00055 (SSARUM2_000011) 11938..12351 + 414 WP_004933919.1 small heat shock chaperone IbpA -
SSARUM2_RS00060 (SSARUM2_000012) 12452..12880 + 429 WP_004933922.1 small heat shock chaperone IbpB -
SSARUM2_RS00065 (SSARUM2_000013) 13047..14705 + 1659 WP_033649549.1 putative transporter -
SSARUM2_RS00070 (SSARUM2_000014) 14716..15096 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
SSARUM2_RS00075 (SSARUM2_000015) 15096..15317 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
SSARUM2_RS00080 (SSARUM2_000016) 15393..16643 - 1251 WP_033645138.1 valine--pyruvate transaminase -
SSARUM2_RS00085 (SSARUM2_000017) 16779..18842 - 2064 WP_060439328.1 alpha-amylase -
SSARUM2_RS00090 (SSARUM2_000018) 19039..19191 + 153 WP_019455508.1 hypothetical protein -
SSARUM2_RS00095 (SSARUM2_000019) 19193..20170 - 978 WP_033636542.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T281203 WP_033649548.1 NZ_CP124754:c15096-14716 [Serratia sp. K-E0102]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT281203 WP_004933932.1 NZ_CP124754:c15317-15096 [Serratia sp. K-E0102]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References