Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4379507..4380102 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S6LRI1
Locus tag SSARUM_RS20760 Protein ID WP_071605322.1
Coordinates 4379848..4380102 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SSARUM_RS20755 Protein ID WP_223294898.1
Coordinates 4379507..4379851 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS20740 (SSARUM_004148) 4375698..4376513 - 816 WP_033649037.1 GPO family capsid scaffolding protein -
SSARUM_RS20745 (SSARUM_004149) 4376656..4378428 + 1773 WP_033649036.1 terminase ATPase subunit family protein -
SSARUM_RS20750 (SSARUM_004150) 4378428..4379462 + 1035 WP_033649034.1 phage portal protein -
SSARUM_RS20755 (SSARUM_004151) 4379507..4379851 - 345 WP_223294898.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SSARUM_RS20760 (SSARUM_004152) 4379848..4380102 - 255 WP_071605322.1 type II toxin-antitoxin system HicA family toxin Toxin
SSARUM_RS20765 (SSARUM_004153) 4380627..4381199 - 573 WP_019843167.1 flavin reductase -
SSARUM_RS20770 (SSARUM_004154) 4381328..4382227 + 900 WP_033649106.1 LysR family transcriptional regulator -
SSARUM_RS20775 (SSARUM_004155) 4382324..4382521 - 198 WP_139818298.1 hypothetical protein -
SSARUM_RS20780 (SSARUM_004156) 4382569..4382766 - 198 WP_033649105.1 hypothetical protein -
SSARUM_RS20785 (SSARUM_004157) 4382840..4385053 - 2214 WP_140926695.1 replication endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-Ic - 4353097..4390909 37812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-101)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9495.97 Da        Isoelectric Point: 11.1073

>T281201 WP_071605322.1 NZ_CP124750:c4380102-4379848 [Serratia sp. K-M0706]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12531.10 Da        Isoelectric Point: 4.5789

>AT281201 WP_223294898.1 NZ_CP124750:c4379851-4379507 [Serratia sp. K-M0706]
MMNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLS
PERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S6LRI1

Antitoxin

Source ID Structure

References