Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3731910..3732566 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4G0W2
Locus tag SSARUM_RS17705 Protein ID WP_041036282.1
Coordinates 3731910..3732299 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag SSARUM_RS17710 Protein ID WP_004941563.1
Coordinates 3732303..3732566 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS17690 (SSARUM_003538) 3728377..3729807 + 1431 WP_060430454.1 multidrug transporter subunit MdtD -
SSARUM_RS17695 (SSARUM_003539) 3729804..3731186 + 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
SSARUM_RS17700 (SSARUM_003540) 3731186..3731902 + 717 WP_033635542.1 two-component system response regulator BaeR -
SSARUM_RS17705 (SSARUM_003541) 3731910..3732299 - 390 WP_041036282.1 type II toxin-antitoxin system VapC family toxin Toxin
SSARUM_RS17710 (SSARUM_003542) 3732303..3732566 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SSARUM_RS17715 (SSARUM_003543) 3732906..3733244 + 339 WP_033635544.1 YegP family protein -
SSARUM_RS17720 (SSARUM_003544) 3733425..3734777 + 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
SSARUM_RS17725 (SSARUM_003545) 3735244..3736149 + 906 WP_033635546.1 lipid kinase YegS -
SSARUM_RS17730 (SSARUM_003546) 3736439..3737488 + 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14309.56 Da        Isoelectric Point: 7.8786

>T281198 WP_041036282.1 NZ_CP124750:c3732299-3731910 [Serratia sp. K-M0706]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT281198 WP_004941563.1 NZ_CP124750:c3732566-3732303 [Serratia sp. K-M0706]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4G0W2

Antitoxin

Source ID Structure

References