Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1553658..1554211 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2V4FZ31
Locus tag SSARUM_RS07425 Protein ID WP_019454426.1
Coordinates 1553897..1554211 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SSARUM_RS07420 Protein ID WP_039566839.1
Coordinates 1553658..1553894 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS07405 (SSARUM_001481) 1550125..1551660 + 1536 WP_033646792.1 glutathione ABC transporter substrate-binding protein GsiB -
SSARUM_RS07410 (SSARUM_001482) 1551713..1552633 + 921 WP_033637716.1 glutathione ABC transporter permease GsiC -
SSARUM_RS07415 (SSARUM_001483) 1552643..1553551 + 909 WP_019454428.1 glutathione ABC transporter permease GsiD -
SSARUM_RS07420 (SSARUM_001484) 1553658..1553894 + 237 WP_039566839.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SSARUM_RS07425 (SSARUM_001485) 1553897..1554211 + 315 WP_019454426.1 CcdB family protein Toxin
SSARUM_RS07430 (SSARUM_001486) 1554251..1555093 - 843 WP_033654970.1 S-formylglutathione hydrolase -
SSARUM_RS07435 (SSARUM_001487) 1555108..1556232 - 1125 WP_033637718.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SSARUM_RS07440 (SSARUM_001488) 1556263..1557183 - 921 WP_033654969.1 LysR family transcriptional regulator -
SSARUM_RS07445 (SSARUM_001489) 1557289..1558446 + 1158 WP_060387473.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.68 Da        Isoelectric Point: 5.0488

>T281191 WP_019454426.1 NZ_CP124750:1553897-1554211 [Serratia sp. K-M0706]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9068.10 Da        Isoelectric Point: 5.7070

>AT281191 WP_039566839.1 NZ_CP124750:1553658-1553894 [Serratia sp. K-M0706]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FZ31

Antitoxin

Source ID Structure

References