Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 500026..501649 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SSARUM_RS02320 Protein ID WP_060430778.1
Coordinates 500327..501649 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SSARUM_RS02315 Protein ID WP_072264934.1
Coordinates 500026..500322 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS02290 (SSARUM_000458) 495909..497294 - 1386 WP_089185441.1 gluconate:H+ symporter -
SSARUM_RS02295 (SSARUM_000459) 497294..498259 - 966 WP_060430776.1 SDR family oxidoreductase -
SSARUM_RS02300 (SSARUM_000460) 498290..499057 - 768 WP_041037671.1 DeoR/GlpR family DNA-binding transcription regulator -
SSARUM_RS02305 (SSARUM_000461) 499113..499367 - 255 WP_140926549.1 hypothetical protein -
SSARUM_RS02315 (SSARUM_000463) 500026..500322 + 297 WP_072264934.1 helix-turn-helix transcriptional regulator Antitoxin
SSARUM_RS02320 (SSARUM_000464) 500327..501649 + 1323 WP_060430778.1 type II toxin-antitoxin system HipA family toxin Toxin
SSARUM_RS02325 (SSARUM_000465) 501860..502405 + 546 WP_060430779.1 hypothetical protein -
SSARUM_RS02330 (SSARUM_000466) 502663..503754 - 1092 WP_060430781.1 type II Zorya anti-phage system protein ZorE -
SSARUM_RS02335 (SSARUM_000467) 503760..504467 - 708 WP_060430783.1 type II Zorya anti-phage system protein ZorB2 -
SSARUM_RS02340 (SSARUM_000468) 504474..506126 - 1653 WP_060430784.1 type II Zorya anti-phage system protein ZorA2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50032.05 Da        Isoelectric Point: 6.3716

>T281188 WP_060430778.1 NZ_CP124750:500327-501649 [Serratia sp. K-M0706]
MRRSQQRLAIWMNGIPVGYWEKRRSEDRLEYLPEWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AIRYHAESLDPFDLLAELGRDCVGAIQLLDIGEQPADIFSIRQRPLAEEQIAEMLRNTATTLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGMVGNMRADMRTSIENEWLCSLIVEHYGVPVASTHIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGVSPLRKYQSDGGPGITDIMEILSRSEQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNNQIAWQKCKLAMAVRGNSNHYLLSQIRRRHWIKHGEITGLGQQEVESIIEELL
ATTPGVIDRVIGLLPNSFPAELAECIFDGIRQQCARLVGG

Download         Length: 1323 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10895.43 Da        Isoelectric Point: 9.0641

>AT281188 WP_072264934.1 NZ_CP124750:500026-500322 [Serratia sp. K-M0706]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLDRLFRVFNVLGIEMVLSSELASPGCE
TEGTSTTHIDSPARREQW

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References