Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14161..14762 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag SSARUM_RS00070 Protein ID WP_033649548.1
Coordinates 14161..14541 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S4X5L5
Locus tag SSARUM_RS00075 Protein ID WP_039568270.1
Coordinates 14541..14762 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS00045 (SSARUM_000009) 9414..10694 + 1281 WP_033649550.1 DUF3748 domain-containing protein -
SSARUM_RS00050 (SSARUM_000010) 10725..11072 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
SSARUM_RS00055 (SSARUM_000011) 11383..11796 + 414 WP_004933919.1 small heat shock chaperone IbpA -
SSARUM_RS00060 (SSARUM_000012) 11897..12325 + 429 WP_004933922.1 small heat shock chaperone IbpB -
SSARUM_RS00065 (SSARUM_000013) 12492..14150 + 1659 WP_033649549.1 putative transporter -
SSARUM_RS00070 (SSARUM_000014) 14161..14541 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
SSARUM_RS00075 (SSARUM_000015) 14541..14762 - 222 WP_039568270.1 ribbon-helix-helix protein, CopG family Antitoxin
SSARUM_RS00080 (SSARUM_000016) 14838..16088 - 1251 WP_060388266.1 valine--pyruvate transaminase -
SSARUM_RS00085 (SSARUM_000017) 16224..18287 - 2064 WP_060388267.1 alpha-amylase -
SSARUM_RS00090 (SSARUM_000018) 18484..18636 + 153 WP_019455508.1 hypothetical protein -
SSARUM_RS00095 (SSARUM_000019) 18638..19615 - 978 WP_060431252.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T281186 WP_033649548.1 NZ_CP124750:c14541-14161 [Serratia sp. K-M0706]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4791

>AT281186 WP_039568270.1 NZ_CP124750:c14762-14541 [Serratia sp. K-M0706]
MTRIVIDLPEEDLRQLDNLKNIRHIPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4X5L5

References