Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3969940..3970589 Replicon chromosome
Accession NZ_CP124744
Organism Proteus mirabilis strain WSY-114

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag QJS45_RS18285 Protein ID WP_012368534.1
Coordinates 3970170..3970589 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag QJS45_RS18280 Protein ID WP_012368535.1
Coordinates 3969940..3970173 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS45_RS18270 (QJS45_18270) 3965584..3966993 - 1410 WP_004246801.1 glutamate--ammonia ligase -
QJS45_RS18275 (QJS45_18275) 3967353..3969188 + 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
QJS45_RS18280 (QJS45_18280) 3969940..3970173 + 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJS45_RS18285 (QJS45_18285) 3970170..3970589 + 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
QJS45_RS18290 (QJS45_18290) 3970859..3971137 + 279 WP_230629709.1 hypothetical protein -
QJS45_RS18295 (QJS45_18295) 3971115..3971531 + 417 WP_046334846.1 hypothetical protein -
QJS45_RS18300 (QJS45_18300) 3972184..3972801 + 618 WP_020946398.1 glucose-1-phosphatase -
QJS45_RS18305 (QJS45_18305) 3972882..3973319 + 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
QJS45_RS18310 (QJS45_18310) 3973343..3974257 + 915 WP_004246811.1 fatty acid biosynthesis protein FabY -
QJS45_RS18315 (QJS45_18315) 3974433..3975311 + 879 WP_282473343.1 23S rRNA pseudouridine(2604) synthase RluF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T281185 WP_012368534.1 NZ_CP124744:3970170-3970589 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT281185 WP_012368535.1 NZ_CP124744:3969940-3970173 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References