Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3691747..3693318 Replicon chromosome
Accession NZ_CP124744
Organism Proteus mirabilis strain WSY-114

Toxin (Protein)


Gene name hipA Uniprot ID B4F0T8
Locus tag QJS45_RS17045 Protein ID WP_012368637.1
Coordinates 3692005..3693318 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag QJS45_RS17040 Protein ID WP_004249771.1
Coordinates 3691747..3692004 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS45_RS17015 (QJS45_17015) 3687709..3687852 + 144 WP_004246509.1 50S ribosomal protein L34 -
QJS45_RS17020 (QJS45_17020) 3687870..3688229 + 360 WP_004246510.1 ribonuclease P protein component -
QJS45_RS17025 (QJS45_17025) 3688193..3688453 + 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
QJS45_RS17030 (QJS45_17030) 3688456..3690096 + 1641 WP_004246512.1 membrane protein insertase YidC -
QJS45_RS17035 (QJS45_17035) 3690234..3691598 + 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
QJS45_RS17040 (QJS45_17040) 3691747..3692004 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
QJS45_RS17045 (QJS45_17045) 3692005..3693318 + 1314 WP_012368637.1 type II toxin-antitoxin system HipA family toxin Toxin
QJS45_RS17050 (QJS45_17050) 3693720..3694184 + 465 WP_004249773.1 DUF1097 domain-containing protein -
QJS45_RS17055 (QJS45_17055) 3694369..3695298 + 930 WP_004246518.1 metallophosphoesterase -
QJS45_RS17060 (QJS45_17060) 3695330..3697291 + 1962 WP_282473319.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
QJS45_RS17065 (QJS45_17065) 3697345..3698148 - 804 WP_282473320.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49670.78 Da        Isoelectric Point: 6.5023

>T281184 WP_012368637.1 NZ_CP124744:3692005-3693318 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT281184 WP_004249771.1 NZ_CP124744:3691747-3692004 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4F0T8

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References