281182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 2225074..2226511 Replicon chromosome
Accession NZ_CP124744
Organism Proteus mirabilis strain WSY-114

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag QJS45_RS10275 Protein ID WP_060555088.1
Coordinates 2225438..2226511 (-) Length 358 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag QJS45_RS10270 Protein ID WP_060555086.1
Coordinates 2225074..2225445 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS45_RS10245 (QJS45_10245) 2222010..2222510 + 501 WP_049197309.1 siphovirus Gp157 family protein -
QJS45_RS10250 (QJS45_10250) 2222558..2222737 + 180 WP_004250516.1 hypothetical protein -
QJS45_RS10255 (QJS45_10255) 2222765..2222935 + 171 WP_020945461.1 hypothetical protein -
QJS45_RS10260 (QJS45_10260) 2223350..2223562 + 213 WP_036908181.1 hypothetical protein -
QJS45_RS10265 (QJS45_10265) 2223564..2224739 + 1176 WP_196575042.1 site-specific integrase -
QJS45_RS10270 (QJS45_10270) 2225074..2225445 - 372 WP_060555086.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
QJS45_RS10275 (QJS45_10275) 2225438..2226511 - 1074 WP_060555088.1 type II toxin-antitoxin system RnlA family toxin Toxin
QJS45_RS10280 (QJS45_10280) 2226962..2227345 - 384 WP_060555090.1 hypothetical protein -
QJS45_RS10285 (QJS45_10285) 2227426..2227560 - 135 Protein_2007 site-specific integrase -
QJS45_RS10290 (QJS45_10290) 2227547..2227882 - 336 WP_060555092.1 hypothetical protein -
QJS45_RS10295 (QJS45_10295) 2228499..2228774 + 276 WP_227201464.1 hypothetical protein -
QJS45_RS10300 (QJS45_10300) 2228960..2229430 + 471 WP_004247039.1 PH domain-containing protein -
QJS45_RS10305 (QJS45_10305) 2229543..2229695 - 153 WP_004247038.1 hypothetical protein -
QJS45_RS10310 (QJS45_10310) 2229765..2229983 - 219 Protein_2012 hypothetical protein -
QJS45_RS10315 (QJS45_10315) 2229986..2230354 - 369 WP_223232026.1 DUF1073 domain-containing protein -
QJS45_RS10320 (QJS45_10320) 2230297..2230764 - 468 WP_282473217.1 hypothetical protein -
QJS45_RS10325 (QJS45_10325) 2230870..2231055 + 186 WP_004247035.1 type II toxin-antitoxin system HicA family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2176888..2237652 60764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-88)

Antitoxin

Antitoxin RnlB/LsoB

(14-111)


Sequences

Toxin        


Download         Length: 358 a.a.        Molecular weight: 40621.81 Da        Isoelectric Point: 6.5823

>T281182 WP_060555088.1 NZ_CP124744:c2226511-2225438 [Proteus mirabilis]
MTVRSYQDLNLDRANIETECRQFIQTRAYTVQSIGPMPGQRPGLRVTFAKIGENFATVNIFYNGNGSCTVQYLTGANRPL
GKELADYLFETINPAEFEHVNMVLEGFVENTILPVLELSAEETHIEFREHLRNHHSIMWKITSTTNQDELTVTLHTTTGK
LQIQGRPLSCYRVFIFNIAELLNLQGLEKVLIRQDDGKANIVQQEVARANLESIMGDAYPCLHAAAEKLLISGLCVKLAA
PKLPDYCMLLYPELRSIEGVLKNKMYAFGMSVQQPLGFGPFFDKVGLNYTLKLQYANTLRPEQVNIINDAYTFWNQERHA
VFHMETVVDTSRMISDMARLMTKATKAWQIIKDLYIV

Download         Length: 1074 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13830.05 Da        Isoelectric Point: 4.3135

>AT281182 WP_060555086.1 NZ_CP124744:c2225445-2225074 [Proteus mirabilis]
MFEITRVNVSGSLKAVVMATSYENPLSSVNEIEMKLTGLLGECENGKILFDLLCSNGPEWNRFVTLEIRLGRIMLDSAQI
IDQKEIPAQILSKLTFILQNHPEYLEASVLTPDDVRQVLSMDM

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References