281181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 493070..494091 Replicon chromosome
Accession NZ_CP124744
Organism Proteus mirabilis strain WSY-114

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag QJS45_RS02185 Protein ID WP_004249488.1
Coordinates 493070..493639 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag QJS45_RS02190 Protein ID WP_004245528.1
Coordinates 493639..494091 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS45_RS02180 (QJS45_02180) 490600..492954 - 2355 WP_017628571.1 DNA polymerase II -
QJS45_RS02185 (QJS45_02185) 493070..493639 - 570 WP_004249488.1 PIN domain-containing protein Toxin
QJS45_RS02190 (QJS45_02190) 493639..494091 - 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
QJS45_RS02195 (QJS45_02195) 494219..494920 - 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
QJS45_RS02200 (QJS45_02200) 494913..496493 - 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
QJS45_RS02205 (QJS45_02205) 496493..497458 - 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
QJS45_RS02210 (QJS45_02210) 497775..498305 + 531 WP_004245524.1 RNA pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T281181 WP_004249488.1 NZ_CP124744:c493639-493070 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT281181 WP_004245528.1 NZ_CP124744:c494091-493639 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References