281170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5124501..5124972 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QI555_RS25385 Protein ID WP_001303511.1
Coordinates 5124501..5124779 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QI555_RS25390 Protein ID WP_001302048.1
Coordinates 5124781..5124972 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS25355 (5119726) 5119726..5119977 - 252 WP_000005552.1 excisionase family protein -
QI555_RS25360 (5120050) 5120050..5122521 - 2472 WP_000048458.1 exonuclease -
QI555_RS25365 (5122614) 5122614..5122805 - 192 WP_001090200.1 DUF1482 family protein -
QI555_RS25370 (5122802) 5122802..5122990 - 189 WP_000449192.1 cell division inhibition protein DicB -
QI555_RS25375 (5123559) 5123559..5123777 - 219 WP_001171930.1 protein YdfC -
QI555_RS25380 (5123849) 5123849..5124148 - 300 WP_001240334.1 hypothetical protein -
QI555_RS25385 (5124501) 5124501..5124779 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QI555_RS25390 (5124781) 5124781..5124972 - 192 WP_001302048.1 hypothetical protein Antitoxin
QI555_RS25395 (5124993) 5124993..5125364 - 372 WP_001169686.1 hypothetical protein -
QI555_RS25400 (5125462) 5125462..5125764 + 303 WP_000172738.1 transcriptional regulator -
QI555_RS25405 (5125761) 5125761..5126186 + 426 WP_000693943.1 toxin YdaT family protein -
QI555_RS25410 (5126209) 5126209..5127171 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
QI555_RS25415 (5127178) 5127178..5127918 + 741 WP_000788938.1 ATP-binding protein -
QI555_RS25420 (5127944) 5127944..5128713 + 770 Protein_4963 DUF1627 domain-containing protein -
QI555_RS25425 (5128729) 5128729..5129124 + 396 WP_001118159.1 DUF977 family protein -
QI555_RS25430 (5129181) 5129181..5129765 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5109621..5138767 29146
- inside Prophage - - 5116214..5138767 22553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T281170 WP_001303511.1 NZ_CP124740:c5124779-5124501 [Escherichia coli O157:H7 str. EDL933]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT281170 WP_001302048.1 NZ_CP124740:c5124972-5124781 [Escherichia coli O157:H7 str. EDL933]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References