Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826432..3827138 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P9WF49
Locus tag RVBD_RS18010 Protein ID WP_003917170.1
Coordinates 3826728..3827138 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF23
Locus tag RVBD_RS18005 Protein ID WP_003417995.1
Coordinates 3826432..3826731 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS17985 3822442..3824043 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
RVBD_RS17990 3824060..3824764 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
RVBD_RS17995 3824882..3825448 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
RVBD_RS18000 3825510..3826397 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
RVBD_RS18005 3826432..3826731 + 300 WP_003417995.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RVBD_RS18010 3826728..3827138 + 411 WP_003917170.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS18015 3827171..3828907 - 1737 WP_003418002.1 cholesterol oxidase -
RVBD_RS18020 3828963..3830090 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
RVBD_RS18025 3830110..3831699 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-118)

Antitoxin

(10-61)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14669.76 Da        Isoelectric Point: 5.1784

>T28116 WP_003917170.1 NC_018143:3826728-3827138 [Mycobacterium tuberculosis H37Rv]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T28116 NC_018143:3826728-3827138 [Mycobacterium tuberculosis H37Rv]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTCGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11009.66 Da        Isoelectric Point: 10.7399

>AT28116 WP_003417995.1 NC_018143:3826432-3826731 [Mycobacterium tuberculosis H37Rv]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGRKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT28116 NC_018143:3826432-3826731 [Mycobacterium tuberculosis H37Rv]
ATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGT
TGAAGCCGGCGAGGAACTTGGCGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTT
CTCGCGAAGCCCTGATTGAATCAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCG
GCGCGCGGCCGCAAGCGCACCCTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A5U883


Antitoxin

Source ID Structure
AlphaFold DB A0A045H9T3

References