Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3020640..3021271 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name hicA Uniprot ID Q8X5S6
Locus tag QI555_RS14790 Protein ID WP_001259386.1
Coordinates 3020640..3020915 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QI555_RS14795 Protein ID WP_000593555.1
Coordinates 3020912..3021271 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS14775 (3015644) 3015644..3016711 + 1068 WP_000361458.1 HlyD family secretion protein -
QI555_RS14780 (3016708) 3016708..3019443 + 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
QI555_RS14785 (3019443) 3019443..3020567 + 1125 WP_001301659.1 ABC transporter permease -
QI555_RS14790 (3020640) 3020640..3020915 + 276 WP_001259386.1 type II toxin-antitoxin system HicA family toxin Toxin
QI555_RS14795 (3020912) 3020912..3021271 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QI555_RS14800 (3021321) 3021321..3022181 - 861 WP_001131788.1 class II aldolase -
QI555_RS14805 (3022213) 3022213..3022482 - 270 WP_000933060.1 HPr family phosphocarrier protein -
QI555_RS14810 (3022472) 3022472..3023980 - 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
QI555_RS14815 (3023973) 3023973..3025331 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
QI555_RS14820 (3025408) 3025408..3025689 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
QI555_RS14825 (3025686) 3025686..3026159 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3011784..3021271 9487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10165.92 Da        Isoelectric Point: 10.7076

>T281159 WP_001259386.1 NZ_CP124740:3020640-3020915 [Escherichia coli O157:H7 str. EDL933]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKLILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT281159 WP_000593555.1 NZ_CP124740:3020912-3021271 [Escherichia coli O157:H7 str. EDL933]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9WXY7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References