Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2211950..2212447 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QI555_RS11055 Protein ID WP_001173343.1
Coordinates 2211950..2212123 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QI555_RS11060 Protein ID WP_000398619.1
Coordinates 2212151..2212447 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS11045 (2208620) 2208620..2210077 + 1458 WP_000856824.1 dipeptide/tripeptide permease DtpC -
QI555_RS11050 (2210314) 2210314..2211831 + 1518 WP_001295074.1 lysine--tRNA ligase -
QI555_RS11055 (2211950) 2211950..2212123 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QI555_RS11060 (2212151) 2212151..2212447 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QI555_RS11065 (2212674) 2212674..2212946 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QI555_RS11070 (2212958) 2212958..2213188 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QI555_RS11075 (2213369) 2213369..2215000 + 1632 WP_001216477.1 sensor histidine kinase -
QI555_RS11080 (2214997) 2214997..2215716 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T281158 WP_001173343.1 NZ_CP124740:c2212123-2211950 [Escherichia coli O157:H7 str. EDL933]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT281158 WP_000398619.1 NZ_CP124740:c2212447-2212151 [Escherichia coli O157:H7 str. EDL933]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References