281157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2114959..2115554 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QI555_RS10555 Protein ID WP_000239579.1
Coordinates 2114959..2115309 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag QI555_RS10560 Protein ID WP_001223210.1
Coordinates 2115303..2115554 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS10535 (2110405) 2110405..2111427 - 1023 WP_001301928.1 ABC transporter permease -
QI555_RS10540 (2111441) 2111441..2112943 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
QI555_RS10545 (2113083) 2113083..2114039 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QI555_RS10550 (2114349) 2114349..2114879 + 531 WP_000055075.1 inorganic diphosphatase -
QI555_RS10555 (2114959) 2114959..2115309 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QI555_RS10560 (2115303) 2115303..2115554 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QI555_RS10565 (2115766) 2115766..2116107 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QI555_RS10570 (2116110) 2116110..2119889 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T281157 WP_000239579.1 NZ_CP124740:c2115309-2114959 [Escherichia coli O157:H7 str. EDL933]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT281157 WP_001223210.1 NZ_CP124740:c2115554-2115303 [Escherichia coli O157:H7 str. EDL933]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References