281154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1865671..1866221 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag QI555_RS09495 Protein ID WP_001160975.1
Coordinates 1865671..1865985 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QI555_RS09500 Protein ID WP_000125566.1
Coordinates 1865988..1866221 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS09470 (1861346) 1861346..1862632 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QI555_RS09475 (1862632) 1862632..1863621 + 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QI555_RS09480 (1863618) 1863618..1864439 + 822 WP_001065380.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QI555_RS09485 (1864442) 1864442..1864819 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QI555_RS09490 (1864826) 1864826..1865674 + 849 WP_000257187.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QI555_RS09495 (1865671) 1865671..1865985 - 315 WP_001160975.1 CcdB family protein Toxin
QI555_RS09500 (1865988) 1865988..1866221 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QI555_RS09505 (1866307) 1866307..1866786 - 480 WP_000624372.1 type 3 dihydrofolate reductase -
QI555_RS09510 (1866978) 1866978..1868840 - 1863 WP_000377184.1 glutathione-regulated potassium-efflux system protein KefC -
QI555_RS09515 (1868833) 1868833..1869363 - 531 WP_000600700.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QI555_RS09520 (1869471) 1869471..1870802 - 1332 WP_001183177.1 MFS transporter -
QI555_RS09525 (1870860) 1870860..1871147 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T281154 WP_001160975.1 NZ_CP124740:c1865985-1865671 [Escherichia coli O157:H7 str. EDL933]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT281154 WP_000125566.1 NZ_CP124740:c1866221-1865988 [Escherichia coli O157:H7 str. EDL933]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References