Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1374251..1374869 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QI555_RS07185 Protein ID WP_001291435.1
Coordinates 1374651..1374869 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QI555_RS07180 Protein ID WP_000344800.1
Coordinates 1374251..1374625 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS07170 (1369340) 1369340..1370533 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QI555_RS07175 (1370556) 1370556..1373705 + 3150 WP_001132452.1 efflux RND transporter permease AcrB -
QI555_RS07180 (1374251) 1374251..1374625 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QI555_RS07185 (1374651) 1374651..1374869 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QI555_RS07190 (1375041) 1375041..1375592 + 552 WP_000102553.1 maltose O-acetyltransferase -
QI555_RS07195 (1375708) 1375708..1376178 + 471 WP_000136192.1 YlaC family protein -
QI555_RS07200 (1376342) 1376342..1377892 + 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QI555_RS07205 (1377934) 1377934..1378287 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QI555_RS07215 (1378666) 1378666..1378977 + 312 WP_000409911.1 MGMT family protein -
QI555_RS07220 (1379010) 1379010..1379582 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281152 WP_001291435.1 NZ_CP124740:1374651-1374869 [Escherichia coli O157:H7 str. EDL933]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT281152 WP_000344800.1 NZ_CP124740:1374251-1374625 [Escherichia coli O157:H7 str. EDL933]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References