281151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 919481..920186 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag QI555_RS05085 Protein ID WP_000539519.1
Coordinates 919481..919867 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QI555_RS05090 Protein ID WP_001280945.1
Coordinates 919857..920186 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS05065 (915485) 915485..916111 + 627 WP_001295292.1 glutathione S-transferase GstB -
QI555_RS05070 (916108) 916108..917223 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
QI555_RS05075 (917334) 917334..917717 - 384 WP_000497137.1 biofilm formation regulator BssR -
QI555_RS05080 (917930) 917930..919255 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QI555_RS05085 (919481) 919481..919867 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QI555_RS05090 (919857) 919857..920186 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QI555_RS05095 (920256) 920256..921584 - 1329 WP_000086905.1 GGDEF domain-containing protein -
QI555_RS05100 (921592) 921592..923940 - 2349 WP_000950320.1 EAL domain-containing protein -
QI555_RS05105 (924118) 924118..925029 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T281151 WP_000539519.1 NZ_CP124740:919481-919867 [Escherichia coli O157:H7 str. EDL933]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT281151 WP_001280945.1 NZ_CP124740:919857-920186 [Escherichia coli O157:H7 str. EDL933]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References