Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 248733..249371 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QI555_RS01310 Protein ID WP_000813794.1
Coordinates 248733..248909 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QI555_RS01315 Protein ID WP_001270286.1
Coordinates 248955..249371 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS01290 (244355) 244355..245566 - 1212 WP_071525382.1 BenE family transporter YdcO -
QI555_RS01295 (245619) 245619..246155 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
QI555_RS01300 (246228) 246228..248189 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QI555_RS01305 (248281) 248281..248511 - 231 WP_000494244.1 YncJ family protein -
QI555_RS01310 (248733) 248733..248909 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QI555_RS01315 (248955) 248955..249371 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QI555_RS01320 (249450) 249450..250856 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
QI555_RS01325 (251101) 251101..252246 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
QI555_RS01330 (252264) 252264..253277 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
QI555_RS01335 (253278) 253278..254219 + 942 WP_001251320.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T281150 WP_000813794.1 NZ_CP124740:248733-248909 [Escherichia coli O157:H7 str. EDL933]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT281150 WP_001270286.1 NZ_CP124740:248955-249371 [Escherichia coli O157:H7 str. EDL933]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References