Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2161705..2162336 Replicon chromosome
Accession NZ_CP124733
Organism Agrobacterium larrymoorei strain CFBP5477

Toxin (Protein)


Gene name vapC Uniprot ID A0A4D7DKT4
Locus tag CFBP5477_RS10465 Protein ID WP_027675859.1
Coordinates 2161705..2162103 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFBP5477_RS10470 Protein ID WP_137393484.1
Coordinates 2162103..2162336 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5477_RS10450 (CFBP5477_010450) 2158794..2159735 + 942 WP_137393481.1 peptidylprolyl isomerase -
CFBP5477_RS10455 (CFBP5477_010455) 2159842..2160858 + 1017 WP_137393482.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
CFBP5477_RS10460 (CFBP5477_010460) 2160858..2161688 + 831 WP_137393483.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CFBP5477_RS10465 (CFBP5477_010465) 2161705..2162103 - 399 WP_027675859.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBP5477_RS10470 (CFBP5477_010470) 2162103..2162336 - 234 WP_137393484.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBP5477_RS10475 (CFBP5477_010475) 2162413..2163081 - 669 WP_137393485.1 guanylate kinase -
CFBP5477_RS10480 (CFBP5477_010480) 2163087..2163974 - 888 WP_137393486.1 YicC/YloC family endoribonuclease -
CFBP5477_RS10485 (CFBP5477_010485) 2164032..2165249 - 1218 WP_027675864.1 endolytic transglycosylase MltG -
CFBP5477_RS10490 (CFBP5477_010490) 2165523..2166785 - 1263 WP_027675865.1 beta-ketoacyl-ACP synthase II -
CFBP5477_RS10495 (CFBP5477_010495) 2166925..2167161 - 237 WP_027675866.1 acyl carrier protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.17 Da        Isoelectric Point: 6.8525

>T281140 WP_027675859.1 NZ_CP124733:c2162103-2161705 [Agrobacterium larrymoorei]
MLTYMLDTNICIYVMKTYPPELREKFNALAEQLCISSITLGELYYGAEKSARRTDNIHAIDNFVARLEVLPFADKAAAHY
GQIRAELTKAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8698.90 Da        Isoelectric Point: 5.0493

>AT281140 WP_137393484.1 NZ_CP124733:c2162336-2162103 [Agrobacterium larrymoorei]
MATSTVFISNRSQAVRLPKAVAFPEDVHKVDVLKIGLTRIIVPQGSRWDDLFLSGPKATQDFLEQREEPALDERESF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DKT4

Antitoxin

Source ID Structure

References